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metaGEM
:gem: An easy-to-use workflow for generating context specific genome-scale metabolic models and predicting metabolic interactions within microbial communities directly from metagenomic data
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TLDR you get higher genomic resolution compared to 16S. Also consider the fact that there is a lot of strain level variation within species, which you completely miss out on without shotgun or long read sequencing. Self plugging our workflow that takes in shotgun sequencing reads, assembles MAGs and then reconstructs metabolic models that can be used for flux balance analysis simulations https://github.com/franciscozorrilla/metaGEM