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Nuitka
Nuitka is a Python compiler written in Python. It's fully compatible with Python 2.6, 2.7, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 3.10, and 3.11. You feed it your Python app, it does a lot of clever things, and spits out an executable or extension module.
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Scout Monitoring
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For Python, you could make a proper deployment binary using Nuitka (in standalone mode – avoid onefile mode for this). I'm not pretending it's as easy as building a Go executable: you may have to do some manual hacking for more unusual unusual packages, and I don't think you can cross compile. I think a key element you're getting at is that Go executables have very few dependencies on OS packages, but with Python (once you've sorted the actual Python dependencies) you only need the packages used for manylinux [2], which is not too onerous.
[1] https://nuitka.net/
[2] https://peps.python.org/pep-0599/#the-manylinux2014-policy
I don't remember the details, and cannot find my notes on vercel/pkg. But looking at https://github.com/vercel/pkg right now I see the project has been deprecated in favour of single-executable-applications
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