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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Aseprite - Free if you follow some complicated steps, paid otherwise. Fully oriented around creating pixel art.
One of my favorites for tilemap creation specifically is Slate (https://github.com/mitchcurtis/slate), otherwise I use gimp or lately pixelorama as others have recommended. Pixelorama is better for animated or static sprites in my opinion, but Slate has a very unique tilemap editor. It is a little complicated at first, but after a bit being able to lay out tiles next to each other and edit them in place is incredible.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.